In fact, on most 4 RAM slot mobos, if you only use 2 sticks, the manufacturer recommends to use slot 2 and 4 and not 1 and 3 because some reason I never understood. Always been using slot 2 and 4. In my current Z370 Taichi I use 2x16Gb, in slot 2 and 4 as recommended
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A good way to compare effective RAM speed is frequency divided by latency.
For example:
F: 1333
L: 14
F/L = 95
F: 1866
L: 19
F/L = 98
So the 1866 RAM would be slightly faster in this case.
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