Actually, imo, the point is that the video driver should IGNORE those sorts of settings for a VR headset. I’d call this a driver bug (not that it helps the situation though).
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I’d say Windows on that. If @dogbite had the dame effect on the rift. Then we’d need to confirm this on Amd gpu & if so then W10 is the root of evil. We need 
. 
I’m not saying it’s a useless setting. It’s just not something to have on by default.
Or … Unity could update it’s engine to not crash with that setting on … Windows is not the culprit here.
Windows is part of the culprit as they changed how windows manages displays & scaling.
I’m sure in future if programs affected by this might be fixed if they have permissions to affect it.